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1771 effect on cardiovascular death in people with CKD and diabetes.
1772 Uncharted decades-long effects: Potential neurocognitive, ocular (NAION optic neuropathy) or other organ-system impacts may
1773 only emerge with widespread, prolonged use. They were
1774 usually cheaper and easier to get, but there were concerns about how they were made and whether they were safe and effective for
1775 long-term use. However, while the GLP-1R has successfully been exploited for the treatment
1776 of type 2 diabetes (T2D), with several pharmacological GLP-1R agonists currently in use clinically or undergoing clinical trials (5),
1777 the GIPR has not until recently been intensively pursued as a T2D treat ment target, primarily due to GIP responses being blunted in T2D patients (6) and the
1778 perception that GIPR activation leads to weight gain, as inferred from the
