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autore: Antonino Tornatore Copyright 2005 - 2025
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2340 Thus, we need approximately **385 patients** with confirmed AMI to estimate sensitivity within ±3% margin.
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2342 Similarly, for specificity:
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2344 Assuming prevalence of disease ~10%, and aiming for same precision, we would require a similar number of non-AMI subjects (~3000). However, given the low prevalence in ED presentations, we might not need that many if we focus on high-risk patients.
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2346 **Alternate Approach**: Use *case-control* design with matched controls to reduce sample size. But this introduces selection bias; thus, for diagnostic test evaluation, a prospective cohort is preferred.
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