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55578 GLP-1 receptor agonists probably reduced all-cause death but may have little or no
55579 effect on cardiovascular death in people with CKD and diabetes.
55580 Uncharted decades-long effects: Potential neurocognitive, ocular (NAION optic neuropathy) or other organ-system impacts may
55581 only emerge with widespread, prolonged use. They were
55582 usually cheaper and easier to get, but there were concerns about how they were made and whether they were safe and effective for
55583 long-term use. However, while the GLP-1R has successfully been exploited for the treatment
55584 of type 2 diabetes (T2D), with several pharmacological GLP-1R agonists currently in use clinically or undergoing clinical trials (5),
55585 the GIPR has not until recently been intensively pursued as a T2D treat ment target, primarily due to GIP responses being blunted in T2D patients (6) and the
