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autore: Antonino Tornatore Copyright 2005 - 2026
59225 observation that GIPR knockout (KO) mice are protected
59226 against the effects of an obesogenic diet (7).
59227 As a result, antagonizing rather than activating the GIPR has been suggested as a potential therapeutic intervention for diabetes and obesity (8, 9).
59228 However, recent data from preclinical and clinical studies ap pear to contradict these
59229 assumptions regarding the role of GIPR in diabetes, as GIPR agonists have been shown to
59230 im prove glucose tolerance and reduce body weight in T2D pa tients (10), and dual GLP-1R/GIPR
59231 targeting peptides, such as the recently developed tirzepatide, have
59232 demonstrated en hanced efficacy compared with currently
