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autore: Antonino Tornatore Copyright 2005 - 2026
27674 usually cheaper and easier to get, but there were concerns about how they were made and whether they were safe and effective for
27675 long-term use. However, while the GLP-1R has successfully been exploited for the treatment
27676 of type 2 diabetes (T2D), with several pharmacological GLP-1R agonists currently in use clinically or undergoing clinical trials (5),
27677 the GIPR has not until recently been intensively pursued as a T2D treat ment target, primarily due to GIP responses being blunted in T2D patients (6) and the
27678 perception that GIPR activation leads to weight gain, as inferred from the
27679 observation that GIPR knockout (KO) mice are protected
27680 against the effects of an obesogenic diet (7).
27681 As a result, antagonizing rather than activating the GIPR has been suggested as a potential therapeutic intervention for diabetes and obesity (8, 9).
