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74 effect on cardiovascular death in people with CKD and diabetes.
75 Uncharted decades-long effects: Potential neurocognitive, ocular (NAION optic neuropathy) or other organ-system impacts may
76 only emerge with widespread, prolonged use. They were
77 usually cheaper and easier to get, but there were concerns about how they were made and whether they were safe and effective for
78 long-term use. However, while the GLP-1R has successfully been exploited for the treatment
79 of type 2 diabetes (T2D), with several pharmacological GLP-1R agonists currently in use clinically or undergoing clinical trials (5),
80 the GIPR has not until recently been intensively pursued as a T2D treat ment target, primarily due to GIP responses being blunted in T2D patients (6) and the
81 perception that GIPR activation leads to weight gain, as inferred from the
